Medical science usually refers to primigravida over the age of 35 as advanced maternal age, and the overall checkup program during pregnancy is slightly different from that of ordinary mothers. The checkup program for advanced maternal age during pregnancy includes routine blood test, blood biochemistry, thyroid function, NT test, glucose tolerance monitoring, non-invasive DNA test and amniocentesis, fetal heart monitoring, pelvic measurement, etc. Specific analysis: 1. Routine program: including routine blood test, fasting blood glucose, liver and kidney function, lipids, thyroid function, blood pressure, urine routine, etc.; 2, NT test: conducted at 11-13+6 weeks of pregnancy, it can be used to assess whether the fetus has Down syndrome by ultrasound examination of the thickness of the nuchal translucency layer; 3, glucose tolerance test: generally conducted at 24-28 weeks of pregnancy, used for screening of gestational diabetes; 4, non-invasive DNA testing, amniocentesis: generally pregnant women will be advised to have amniocentesis or non-invasive DNA testing. 5. Exclusion test: Prenatal ultrasound screening at 20-24 weeks of pregnancy can detect serious fetal structural abnormalities, such as anencephaly, severe open spina bifida, single-chambered heart, etc.; 6. Fetal heart monitoring: Mothers of advanced maternal age should pay close attention to the baby’s fetal movement when approaching the expected date of delivery, and fetal heart testing is required every week; 7. Pelvic measurements: pelvis measurement is divided into external and internal measurements. Pelvic measurement: pelvic measurement is divided into external measurement and internal measurement, mainly measuring the size of the pelvic inlet and outlet of the pregnant mother, which is used to assess the appropriate mode of delivery. Due to the special characteristics of elderly women, the maternity checkup program should be strictly perfected during pregnancy, and the number of checkups can be increased appropriately according to the specific situation to ensure the development of the fetus.