Trigeminal neuralgia is one of the most common, persistent, and painful painful disorders with an incidence of 182.8/100,000 people, occurring mainly in middle-aged and elderly people, and more in women than men. The pain is mostly unilateral. It usually manifests as facial tearing-like, electric shock-like, lightning-like, pins-and-needles, knife-like, or burning-like severe pain, most pronounced in the cheek, upper jaw, lower jaw, or the front 2/3 of the tongue. In many patients, pain is triggered by the slightest touch on the outer lip, nose, cheek, tongue, etc., called “trigger points”. Trigeminal neuralgia attacks are usually unpredictable and last from a few seconds to several minutes. The pain lasts from a few seconds to a few minutes, and it is sudden and stops suddenly, with no pain in the intervals. Patients are afraid to wash their faces, shave, brush their teeth and eat for fear of painful attacks, so their oral and facial hygiene is very poor, and they suffer from general malnutrition, emaciation, depression and low mood. Long-term disease can produce neurotrophic disorders, such as local facial skin roughness, eyebrow loss, etc. Patients with severe pain often roll over in bed during attacks and have suicidal thoughts, so trigeminal neuralgia is also known as the “cancer that cannot die”. The common treatments for trigeminal neuralgia include oral carbamazepine, microvascular decompression surgery, radiofrequency thermal coagulation destruction of the semilunar ganglion, peripheral branch avulsion, gamma knife, etc. Among them, oral medication, microvascular decompression and radiofrequency surgery are classical treatments that have been clinically tested for a long time. Patients with mild pain at the beginning of the disease can use carbamazepine to control the pain, but carbamazepine and other drugs are toxic to the liver and kidneys, and long-term or high doses can cause irreversible damage to the liver and kidneys. The indications for microvascular decompression surgery are relatively strict. It must be determined by cranial MRI examination that there are blood vessels compressing the trigeminal nerve, and it needs to be operated intracranially through the postauricular mastoid perforation under general anesthesia with tracheal intubation, which is often very serious in case of surgical accidents, and there is also the problem of expensive surgery and anesthesia, which is unacceptable to many patients. Traditional radiofrequency thermal coagulation destruction of the hemianopia is to rely on anatomical relationships to blindly puncture, and then determine whether the location of the puncture needle is good through electrical stimulation, and then use radiofrequency heat to cut off the diseased trigeminal nerve after positioning, the whole puncture and destruction process requires the cooperation of the patient, who is completely awake. The key to successful RF surgery lies in the accuracy of positioning, but blind puncture often does not guarantee the accurate position and depth of the puncture needle. During RF destruction, because of the strong stimulation of the trigeminal nerve, patients often experience a short period of severe pain, which has a great impact on the patient’s psychology. CT-guided radiofrequency thermocoagulation destruction of the semilunar ganglion can be performed, compounded with small doses of isoproterenol for intravenous general anesthesia, allowing the patient to undergo the procedure in a brief deep sleep. Using the precise guidance of CT, the position, angle and depth of the puncture needle can be clearly seen, so the puncture direction can be adjusted according to the results of the CT scan, ensuring the accuracy of the puncture. Intravenous general anesthesia with isoproterenol avoids the pain caused by severe nerve stimulation during destruction, and patients often feel that “the surgery is over after a good night’s sleep”. The development and promotion of CT-guided radiofrequency thermal coagulation disruption of the meningeal ganglion is a blessing for patients with trigeminal neuralgia.