Jaundice is caused by a high level of bilirubin in the blood that exceeds the metabolic capacity of the liver. Common diseases that cause jaundice include massive destruction of red blood cells, liver disease, bile duct disease, etc. If jaundice is detected, liver function and hepatobiliary ultrasound should be performed to determine whether there is hepatitis, biliary obstruction, or hematologic disease, and if jaundice is diagnosed to be caused by these diseases, appropriate treatment can be given according to the primary disease. Neonatal jaundice is mainly caused by the destruction of red blood cells resulting in the metabolism of large amounts of hemoglobin and the limited level of bilirubin metabolized by the newborn’s liver. Physiological jaundice in newborns is due to environmental changes before and after birth, which is unavoidable, while bilirubin levels in physiological jaundice have little impact on human health, so special treatment is generally not required. If jaundice appears too early and the bilirubin level is too high, attention should be paid to timely blue light treatment to lower the bilirubin level, as well as to check to rule out pathological jaundice and to treat it accordingly according to the primary disease causing the jaundice. Jaundice itself is not an isolated disease, but a clinical symptom caused by hepatobiliary disease and red blood cell destruction, and the treatment of jaundice is mainly for the treatment of the primary disease, so when jaundice appears clinically, we should actively seek medical attention and give appropriate treatment according to the primary disease.