Stay up all night chest tightness is generally considered to be related to cardiac neurological dysfunction, this time need to rest or appropriate oral vitamin drugs to improve the symptoms, but can not be excluded coronary heart disease, angina pectoris and other cardiovascular diseases may be, generally can be temporarily contained in the service of nitroglycerin or fast-acting heart pills to alleviate. 1. Cardiac neurological dysfunction, after staying up all night autonomic nervous function over-excitement, at this time there will be a faster heart rate, increased myocardial oxygen consumption, resulting in chest tightness. General rest can alleviate this discomfort, and can take appropriate oral medications (such as glutamine tablets, vitamin B1, etc.) to regulate the function of plant nerves, relieve the sympathetic over-excitement caused by staying up late and chest tightness, and try to avoid staying up late in the future. 2. Coronary heart disease, angina pectoris patients may be induced by staying up late myocardial ischemia aggravation, chest tightness, at this time you can temporarily take nitroglycerin or fast-acting heart pills, and go to the hospital in a timely manner to improve the electrocardiogram, coronary CTA and other tests. If the patient appears to stay up all night chest tightness, the above methods can not be relieved, should be taken seriously, consider whether there is a myocardial infarction and other critical illnesses, should go to the hospital as soon as possible, identify the cause of the disease, and comply with the doctor’s instructions for treatment.