Chest pain during activity and normal at rest may be caused by myocardial ischemia, intercostal neuralgia, pleurisy and other reasons. 1. Myocardial ischemia: when overwork and emotional excitement, the load on the heart increases, and atherosclerosis occurs in the coronary arteries of the heart, resulting in narrowing of the lumen will cause myocardial ischemia, causing chest pain and chest tightness and other symptoms to occur in the course of the patient’s labor. 2. Intercostal neuralgia: mostly caused by intercostal nerve compression, viral infection, trauma, etc., along the distribution of the nerves in the area of pain in the strip, fatigue, cold, etc., easily induced, aggravated by the activities of the disease-related factors can lead to pain, and can be relieved after rest. 3. Pleurisy: If you suffer from pleurisy, inflammatory factors will be released to the pleural surface, resulting in an increase in the amount of pleural water between the dirty pleura and the wall pleura, and also chest pain, chest tightness and other symptoms. In the early stages of the lesion, the symptoms of chest pain may manifest during exercise. When the symptom of chest pain during activity and normal at rest occurs, please do not self-medicate, it is recommended to go to the hospital in time to identify the cause of the disease and treat the symptoms under the guidance of the doctor.