Neurasthenia may affect premature ejaculation. Neurasthenia generally has no organic lesions, and can be caused by psychogenic reactions to premature ejaculation. Neurasthenia is the organism is under long-term tension and stress, causing long-term sleep disorders, anxiety, depression, mental excitability and cerebral fatigue, the patient may have symptoms of premature ejaculation. Premature ejaculation caused by neurasthenia is usually caused by psychogenic reasons, not caused by organic lesions. In the treatment can be considered with anti-anxiety, antidepressant drugs, such as dapoxetine, sertraline, can improve the anxiety and depression accompanied by neurasthenia, so that muscle relaxation, may improve the symptoms of premature ejaculation. Neurasthenia should pay attention to the regulation of emotions, avoid producing excitement, anxiety, depression and other negative emotions, usually regular work and rest, sleep on time, pay attention to the combination of work and rest, to avoid excessive physical exertion. Neurasthenia appeared premature ejaculation is more serious, it is recommended to consult a doctor, the above drugs used in accordance with the doctor’s instructions.