Hepatosplenomegaly can present with abdominal pain, masses, jaundice, and coagulation dysfunction, as follows: First, abdominal pain: Patients can have distending pain in the left and right abdomen, which is usually persistent. Second, the mass: in the left abdomen and the right abdomen can be touched hard mass, its activity is poor, generally no obvious pressure pain. Third, jaundice: jaundice is manifested by yellowing of the skin and eyes, combined with deepening of the urine and white stools. Fourth, coagulation dysfunction: Sometimes patients can develop coagulation dysfunction, which is manifested by localized bleeding from touching, and blood does not love to coagulate. After finding hepatosplenomegaly, you need to go to the hospital as soon as possible to improve the examination, such as blood routine, four items of coagulation, liver function, and tumor markers such as methemoglobin, carcinoembryonic antigen, and glycoantigen 19-9, etc. You also need to check abdominal enhancement CT, abdominal MRI, etc. and carry out treatment according to the results.