Chest pain when smoking is considered to be caused by respiratory and circulatory diseases, and patients should be treated according to the symptoms of different diseases. 1. Respiratory diseases: Chest pain caused by smoking may be caused by respiratory diseases, pharyngitis, respiratory mucous membrane irritation, and bronchitis can cause chest pain. Antibiotics, such as azithromycin, penicillin and erythromycin, can be used under the guidance of the doctor. 2. Circulatory system diseases: when patients smoke, it will reduce the oxygen content in the blood, and for patients with heart disease, it is easy to trigger angina, resulting in insufficient blood supply to the heart. Patients can improve the symptoms of chest pain by quitting smoking, increase some aerobic exercise, or use clopidogrel, nitroglycerin and other comprehensive treatment under the guidance of a doctor. When patients have chest pain when smoking, it is recommended to go to the hospital as soon as possible, to clarify the cause of the disease, and timely and appropriate treatment.