In the process of IVF, many couples have already reaped the joyous results, while some infertile women have failed to get pregnant even after multiple embryo transfers. Clinically, failure to achieve pregnancy after 3 or more transfers of good quality embryos is known as recurrent transfer failure, and it is a challenge that both doctors and patients have to face. The reasons for repeated transfer failures include the embryo, the uterus, and the interrelationship between the embryo and the uterus. Embryonic factors: A poor quality egg and sperm can fertilize to form a normal looking embryo, but this embryo has poor developmental potential and cannot implant into the uterine lining for implantation or does not continue to develop after implantation. For this reason, embryologists allow day 3 embryos to continue to develop in the laboratory until they reach day 5-6 blastocysts and then transfer them, known as blastocyst culture and blastocyst transfer, so that some of the poor embryos are eliminated due to failure to continue to develop; some cells can also be taken from the embryo to check for abnormalities and to select high-quality embryos for transfer, known as pre-implantation genetic screening; and the shell of the embryo can be thinned for embryo implantation by using microscopic manipulation techniques. Microscopic manipulation techniques can also be used to make the embryo shell thinner to facilitate embryo implantation, known as assisted hatching treatment, these measures are conducive to the implantation of high-quality embryos and improve the success rate. 2, uterine factors: thin endometrium, endometrial inflammation, adhesions, polyps, uterine submucosal fibroids, uterine malformation are not conducive to embryo implantation, repeated implantation failure patients should be hysteroscopy, clear whether there are abnormalities in the uterine cavity, and appropriate treatment will often improve the success rate, tubal hydrosalpinx, polycystic ovary syndrome, endometriosis on the embryo implantation has an impact on the corresponding treatment is conducive to improve the prognosis. The prognosis will be improved after appropriate treatment. 3, the interrelationship between the uterus and embryo: There may be more communication and communication between the uterus and the embryo, if the communication obstacle, it will also affect the implantation of the embryo, the doctor will use the uterine cavity light scratching, intrauterine injection of drugs, immune cells, inflammatory factors, intravenous injection of immunoglobulin, active immunotherapy, hope that through these ways to improve the communication and communication between the uterus and the embryo, reduce the rejection of the embryo thereby increasing pregnancy rates. Repeated implantation failures are a challenge, and through continuous improvement in medical technology, we believe that more infertile couples will achieve a good pregnancy.