In 1925, Kleine reported a group of cases in which the patients were young males who were always asleep at the onset of the disease, except when eating and defecating. These people are always in a sleep state at the onset of the disease, except for eating and urinating and defecating when awake, the patient can be awakened during sleep, and can also get up to relieve themselves, but after waking up, they immediately have to eat, and when eating, the amount of food is surprisingly large, a person a day less than 2 to 3 pounds, more than 5 to 6 pounds of food, when asked why they have to eat so much, the patient will not think twice to answer: “Hungry unbearable. ” If they are not given something to eat, they will make a lot of noise and even curse more than once. The Kleine-Levin syndrome (KLS) was first described as early as 1925: recurrent somnolence, behavioral disturbances (overeating and uncontrolled sexual urges), and psychotic disorders; his description was subsequently affirmed by Levin [2] in 1929.Critchley et al [3], on the other hand, first applied in 1942 KLS to name cases and noted that KLS has the following characteristics: recurrent sleepiness, compulsive eating, irritability/anxiety, increased sexual impulsivity, prevalence in males, and mostly onset in adolescence [4].KLS is a very rare disorder, and as of June 2, 2005, only 177 KLS-related studies have been searched by Pre-MEDLINE and MEDLINE and are case reports were predominant. The paucity of data makes it difficult for most physicians to identify these patients with specific pathological hunger, so Levin also called the disease periodic narcolepsy-pathological hunger syndrome. 2 cases were also reported by Gritchley and Hoffman in 1924, and the disease was named Kleine-Levin syndrome, also known as narcolepsy-bulimia syndrome. . This disease has also been reported in China in recent years. Some people think that it is a malignant form of hysteria rather than an independent disease; others think that it is related to infection and belongs to mild encephalitis; some people think that it is a kind of epilepsy according to the abnormal EEG of the patient. (B) Pathogenesis According to modern medical research on neurobiochemistry, pathology and physiology, it is believed that narcolepsy-bulimia syndrome is a mild latent lesion of the limbic system-hypothalamus-brainstem reticular function after infection, trauma and congenital defects, which causes the patient to develop the disease after puberty due to the dysfunction of the body’s internal environment and endocrine system. What are the manifestations of episodic narcolepsy and strong feeding syndrome and how is it diagnosed? The main symptom is periodic, episodic drowsiness and hyperphagia. The drowsy episodes can be drowsy, open the eyes when called, but cannot speak, indifferent to the surrounding things, easily provoked, during the period there is often hyperphagia, can wake up to eat, sleep again after eating, eating a lot, and accompanied by rapid weight gain (up to 1~2kg per day), with or without psychiatric symptoms, the episodes last 1 day to 2 weeks after Some patients may have endocrine changes, or autonomic dysfunction, etc. The EEG can be normal or moderately abnormal, with a slowing of the basic rhythm to 8-9 times/s alpha rhythm, high amplitude theta waves in both frontal regions, and single gamma waves, etc. CT and MRI scans of the skull and cerebrospinal fluid examination are not abnormal. The diagnosis is not difficult based on the typical periodic episodes of somnolence and hyperphagia, which should be distinguished from narcolepsy, which also has episodic somnolence without hyperphagia and is accompanied by sudden collapse, sleep paralysis, and sleep hallucinations, and MSLT shows pathological REM sleep. What tests should be done for episodic narcolepsy and strong eating syndrome? Multiple sleep latency test (MSLT). Polysomnography (PSG) examination. Examination. On the basis of history taking and neurological examination, other necessary and selective ancillary tests include CT and MRI.