The drugs of note for closure are hormones and local anesthetics. Local anesthetics include procaine, lidocaine, bupivacaine, bupivacaine, etc., and hormones include prednisone, prednisone acetate, Depo-Provera, tretinoin, etc. The effect of local anesthetics is to temporarily block local nerve conduction so that the corresponding areas innervated by these nerves are anesthetized, thus relieving the pain sensation. The role of hormones is to reduce inflammation, relieve pain and release adhesions. Some people heard of playing “closed needle”, will have fear, always think that “closed needle” can only temporarily reduce the symptoms of the disease, and can not solve the problem at the root; or fear of playing “closed needle After the “closed needle”, from then on to keep playing, and even worried about the side effects. In fact, hormone drugs are not addictive, and only in long-term, large doses, repeatedly applied, may appear dependent. In fact, doctors often use closed injections at intervals of 7-14 days or 1 month each time, generally no more than 3-4 times in a row. After that, if you need to continue to inject, the interval will be very long, and the dose used will be very small, so it will rarely produce side effects on the human body. Therefore, closure is still a very safe treatment.