Blisters at the vaginal opening are mainly considered to be related to vulvar eczema, genital herpes, and allergies. Patients should combine with other physical symptoms and go to the hospital in time. Common causes and treatments 1. genital herpes: a sexually transmitted disease caused by herpes simplex virus, manifested as blisters, pain, itching, ulcers and other symptoms in the genital area, treated with antiviral drugs, such as acyclovir, and if serious pain occurs, pain relief drugs can also be used appropriately to relieve pain; 2. vulvar eczema: women of childbearing age have a lot of secretions and a humid environment in the vulva. It is easy to suffer from vulvar eczema, which is a granular bump with obvious itching and even pain and burning sensation, and can be treated with glucocorticoid medication; 3. Allergy: such as applying ointment, using sanitary napkin, wearing new underwear, etc., may lead to local allergy and cause the phenomenon of small blisters. If the itching is serious, patients should not scratch with their hands to avoid skin breakdown and bacterial infection, which will aggravate the condition, and they must do a good job of cleaning their private parts and keep them dry.