Filler powder cannot be used to fill tear troughs and wrinkles, and its clinical effectiveness and safety have not been verified. At present, there is no filler powder filler program in regular public hospitals, the specific composition of the material is unknown, which may lead to allergies, local inflammation, carcinogenicity, filler displacement and other risks, it is recommended to be careful to choose, be sure to choose a regular plastic surgery hospital, in line with the requirements of the State Food and Drug Administration drug treatment. Currently in the clinic commonly used to improve the tear trough, including filling hyaluronic acid, autologous fat, hyaluronic acid belongs to the safe injectable ingredients, can play a filler, moisturizing effect on the skin, but belongs to the non-permanent filler material, general maintenance time 6-12 months, autologous fat need to extract their own fat particles and then fill, can achieve 5 years or even longer clinical effect. In addition, ultrasonic knife, Thermage and other non-surgical methods, the use of ultrasound and thermal effects to enhance the skin, is also commonly used in the tear trough, wrinkle improvement. Filler powder is not commonly used to improve the tear trough and wrinkles, it is recommended that patients who wish to improve the tear trough and wrinkles must choose a regular medical institution to visit, under the guidance of a specialist physician to choose the filler approved by the State Food and Drug Administration for treatment, in order to avoid adverse consequences.