Usually, a change from a major to a minor triple positive is a good thing, indicating a slowdown in viral replication and a decrease in infectiousness. Usually, clinically, it is considered a good thing for a major triple positive to turn into a minor triple positive. Although, both major triple positive and minor triple positive are infected by hepatitis B virus, there are obvious differences between the two. Major triple positive indicates that the hepatitis B virus in the body is replicating, which will further damage liver cells to a certain extent and is highly contagious. When the major triple positive is converted to a minor triple positive, the replication of the virus in the patient’s body is slowed down, and the infectiousness of the virus is also significantly reduced. However, even so, there is still a chance that the minor triple positive will turn into a major triple positive, so at this time, we should actively cooperate with the doctor to continue treatment, and closely monitor the changes of relevant indicators, such as liver function and hepatitis B five. All in all, patients with hepatitis B virus infection need to go to the hospital in time, strengthen the daily life management, and cooperate with the doctor for active treatment, so as to avoid delaying the condition.