Before the development of parametrial cancer, the parametrium is enlarged and swollen with the menstrual cycle. After the onset of parametrial carcinomatosis, the enlargement and pain disappears, and a hard node can be palpated in the armpit with hard texture, unclear border and minimal mobility.
In the advanced stage of parametrial cancer, the cancer cells may metastasise to distant areas and cause multi-organ lesions, with many clinical manifestations, such as oedema, weakness, fever and weight loss.