Premature ejaculation is one of the common clinical urological male diseases and is the most common disease in ejaculation disorders, with an incidence of 35% to 50% of adult men. It seriously affects the quality of sexual life and not only causes great harm to the body and mind of the majority of patients, but also threatens the relationship between husband and wife and family harmony. The definition is still controversial, and usually refers to men who lose the ability to control ejaculation during sexual intercourse, ejaculate before or just after penile insertion into the vagina, or women who achieve orgasm less than 50% of the time during sexual intercourse can be defined as premature ejaculation. Premature ejaculation is usually classified into primary and secondary according to the time. Primary premature ejaculation refers to both premature ejaculation from the first sexual intercourse, while secondary premature ejaculation refers to men who had a period of normal ejaculatory function in the past and then gradually developed premature ejaculation, often secondary to diseases such as erectile dysfunction or reproductive tract infections. The causes of premature ejaculation are not only partly psychosomatic abnormal trends, such as depression, restlessness, psychosis, physicalization and hostility, but also neuropathic organic lesions, and penile sensory hypersensitivity or increased penile sensory nerve excitability to the point of ejaculatory dysfunction regulation and cause premature ejaculation, which needs to be further studied in depth. In addition, external genital and anterior urethral diseases, such as prepuce, glansitis, prostatitis, vesiculitis and urethritis, and other organic lesions can also affect the ejaculatory function. The lack of effective clinical treatment for premature ejaculation, especially primary premature ejaculation, has long plagued urologists and male surgeons with premature ejaculation treatment. Premature ejaculation can be easily diagnosed by taking a medical history. Its treatment should first analyze the cause of its pathogenesis and select appropriate treatment methods according to its pathogenesis. At present, the commonly used clinical treatment methods are: sexy concentration training method, penile pinching therapy, oral medication (antidepressant preparation, Chinese medicine), penile cavernous body drug injection therapy, prosthesis implantation, dorsal penile nerve amputation, local epidermal drug application, etc.