Most of the moles on the soles of the feet are skin diseases due to the increase of epidermal and dermal nevus cells, which are benign skin diseases and usually do not have special significance. Generally, if the nevus is flat with the skin, without pain or itching, with clear edges, uniform color and symmetrical shape, and is not accompanied by other uncomfortable symptoms, it can usually be left untreated. However, if a mole on the bottom of the foot rapidly becomes larger, deepens in color or has painful sensation within a short period of time, and is accompanied by jagged or stellate changes, or if the mole itself grows on a stressed area, has uneven color and asymmetric structure, has a mild bump or shows symptoms such as rupture, erosion, pain and itching, the lesion should be removed in a timely manner in a hospital, usually by complete surgical excision. After excision, pathological tests are usually performed to determine whether the lesion has transformed into a malignant melanoma. If this occurs, a second, expanded excision is required and, if necessary, a whole-body lymph node screening may be performed. In addition, moles on the hands or feet that are more than 0.5 cm in diameter and moles on the nails that are more than 0.3 cm in diameter can be removed prophylactically. It is necessary to strengthen local cleaning care and avoid irritating factors such as scratching and picking to prevent secondary bacterial infection, which may lead to the expansion of the lesion area.