The third vaccine is generally referred to as the New Crown vaccine, which is usually not affected by menstrual irregularities. Unless the patient has a severe allergy to the vaccine components or the menstrual irregularity is accompanied by an acute exacerbation of various diseases. Contraindications to the vaccine include severe allergy to the vaccine components and acute exacerbation of various diseases. Irregular menstruation is a common gynecological disease that manifests itself as abnormalities in menstrual cycle, menstrual period, menstrual flow, etc., and can be accompanied by abdominal pain, dizziness, fatigue and other symptoms before and after menstruation, and is mainly affected by endocrine, infections, organic lesions and other factors. The role of the vaccine is to enhance the preventive effect, so that the body can produce enough antibodies to resist the disease. The third dose of New Crown vaccine can play a preventive role against the mutated strains and reduce the risk of infection. It is recommended to receive the third dose of the vaccine in a timely manner if there are no significant adverse reactions when receiving the first two doses of the vaccine. So far, irregular menstruation is not a contraindication for the new crown vaccine, unless there is an acute exacerbation of the disease. Other than that, it is possible to administer the third vaccine dose without further affecting menstrual disorders. In the event of menstrual disorders, it is necessary to seek medical attention in a timely manner, under the supervision of a doctor for standardized treatment.