Bruising on the hands is related to the use of drugs, soft tissue contusion, hemophilia, acute leukemia, aplastic anemia, and so on. 1. Medication: For some long-term use of anticoagulant and thrombolytic drugs, such as aspirin, clopidogrel, warfarin, etc., it may cause bruises on the hands due to decreased blood clotting function. 2. Soft tissue contusion: when the external object impact or collision of the hand, can be due to blood infiltration into the subcutaneous tissue caused by bruising, but also easy to be accompanied by pain, swelling and other uncomfortable symptoms. 3. Hemophilia: hemophilia is a bleeding disorder caused by hereditary coagulation disorders, and the patient’s subcutaneous tissues, mouth, gums and mucous membranes are prone to bleeding, which is manifested as bruises on the hands. 4. Acute leukemia: the cause of the disease is still unclear, and it is considered to be related to viral infection, abnormal immune function and exposure to radiation. When the disease causes excessive proliferation of blood cells in patients, it is easy to cause fever, hepatosplenomegaly, skin bruising and other symptoms, which are manifested as bruises on the hands. 5. Aplastic anemia: the disease is related to gene mutation, viral infection, chemical factors, etc. Patients mainly have fever, palpitation (rapid heartbeat, often accompanied by panic), bleeding of skin and mucous membranes, dizziness, etc., which can also be manifested as bruises on the hands. It is recommended that people with bruises on their hands consult a regular hospital for examination, so as to clarify the disease and follow the doctor’s instructions for medication.