Mucopolysaccharide storage disease ( MPS) is a group of diseases in which acidic mucopolysaccharide molecules cannot be degraded and accumulate in the lysosomes due to lysosomal enzyme defects. The disease is mainly characterized by skeletal deformities and stunted body development as the main clinical manifestations, with or without mental retardation, heart valve disease, corneal clouding and deafness. According to the clinical manifestations and enzyme defects, mucopolysaccharidoses can be divided into 8 types such as I, II, III, IV, IV, VI, VII, and IX (no type V and VIII). The clinical manifestations and subsequent treatment and prognosis of each type of MPS are different due to the different tissues and degrees involved. To facilitate preliminary clinical identification by parents, the content is shown below: In a classic type I patient, for example, the main clinical features are as follows: 1. Gross facial features: large head, prominent forehead, dense eyebrows, prominent eyeballs, swollen eyelids, low nasal bridge, and upturned nostrils. Lips are large and thick, tongue is large, gums are enlarged, teeth are tiny and widely spaced. The skin hair is thick and rough, and the hairline is low. 2, corneal clouding: As the disease progresses, corneal clouding gradually worsens and can eventually lead to blindness. 3. Hepatosplenomegaly: the abdomen is bulging and the abdominal pressure leads to frequent umbilical and inguinal hernia. 4.Short stature: the affected child has a retroverted spine and delayed physical growth with developmental deformities of the spine, sternum and ribs. 5.Joint stiffness: The involvement of all joints will limit the mobility of these joints and cause joint contracture, such as the involvement of finger joints, showing the characteristics of “claw-shaped hands”; if the involvement of knee joints and hip joints and other large joints, it will lead to unstable gait, walking and falling. 6, intellectual backwardness: patients may show intellectual backwardness or regression at the age of about 1 year, or even serious intellectual disability. 7. Hearing impairment: Hearing impairment is mainly due to the dysfunction of the eustachian tube and repeated middle ear infections, tympanic membrane scarring, and damage to the eighth pair of cranial nerves caused by the developmental disorder of the middle ear bones. 8. Heart: Most patients have cardiac involvement in the later stages of the disease, which manifests as valvular disease and can lead to heart failure. Other types of MPS: Type II MPS patients have slightly less severe symptoms than Type I. Because the type is X-linked recessive inheritance, the affected children are all male, and the patients’ corneas are not cloudy; Type III MPS patients have severe intellectual backwardness as the main clinical manifestation; Type IV MPS patients have more severe skeletal deformities, such as loose wrist joints, the thorax protrudes forward to form a chicken-like chest, while children with modified type have cloudy corneas, but intelligence is generally Type VI patients have normal intelligence, but corneal clouding is obvious; Type VII patients can vary greatly in clinical manifestations, with severe manifestations of hydrops fetalis, and lighter patients can only have short stature and skeletal deformities.