What is moyamoya disease and what are the signs of its onset? Moyamoya is a chronic progressive cerebrovascular occlusive disease of unknown origin, mainly due to chronic progressive stenosis or occlusion of the major bilateral branches of the cerebral arterial ring (the end of the internal carotid artery, the anterior cerebral artery, the middle cerebral artery, and sometimes the beginning of the posterior cerebral artery), followed by the appearance of a network of small vessels with abnormal side branches, which appears in the shape of the smoke exhaled during the cerebral angiography. Smoke disease is the name given to this condition. The disease was first discovered and named by the Japanese in the 1950s and 1960s, so it is also known as “moyamoya disease”, which is the Japanese pronunciation of moyamoya. It is an extremely rare disease, and some patients do not have any aura at the beginning of the disease. Some patients may show symptoms such as dizziness and headache, nausea and vomiting, weakness in one or both limbs, and a significant decrease in mental ability. Many patients and primary health care workers do not know much about smog, but if we associate it with cerebral hemorrhage and cerebral infarction, we believe that we can have a better understanding of it. As a rare disease, smoker’s disease is mostly seen in East Asia such as Japan and Korea. In recent years, the popularity of clinical applications of brain magnetic resonance angiography (MRA) and digital subtraction angiography (DSA) has led to a gradual increase in the detection rate of smog disease in China. Because of the potential danger of smog disease is very harmful to patients, only through scientific and effective treatment can patients get rid of the torment of the disease. At present, combined vascular bypass is an advanced procedure for the treatment of smog, which has been recognized by thousands of patients for getting rid of the disease.