Also known as aortic arch agenesis, it refers to the absence of connection between the ascending and descending aorta. It is a congenital heart disease in which the continuity is interrupted by abnormal development of the aortic arch at five to seven weeks of embryonic development and accounts for about 1 to 4 percent of congenital heart disease. The disease is often associated with ventricular septal defect, ductus arteriosus, and, in some cases, thumb anomalies, called “Halt-Oram syndrome”. The simple type without these deformities is rare. Clinically, it is classified into types A, B and C according to the site of dissection. Due to the physiological characteristics of the fetal left and right ventricles circulating in parallel, growth and development are not affected during the fetal period. After birth, the aorta distant from the dissection receives blood supply from the right ventricle through the unclosed ductus arteriosus, and therefore, catastrophic results occur once the ductus arteriosus is closed. The combined malformations of this disease include: ventricular septal defect, unclosed arterial duct, common arterial trunk, aortic valve diastasis, subaortic stenosis, mitral valve malformation, thymic tissue deficiency such as hypocalcemic immunodeficiency called Di George’s syndrome, single ventricle, transposition of great vessels, and endocardial cushion defect in fewer cases. Health care measures: 1. No special therapeutic care is needed during the fetal period; 2. Normal delivery can be awaited without special delivery measures; 3. Cardiac ultrasound and CT examinations are performed immediately after birth to clarify the diagnosis and actively prepare for surgery; 4. Intravenous pumping of Pau d’Arco (prostaglandin E1) keeps the arterial catheter open, monitors blood pressure and oxygen saturation in the lower extremities, and maintains circulatory function and stability of the internal environment. Treatment: Emergency or limited time surgical treatment.