Laryngopharyngeal reflux (LPR) refers to the reflux of gastric contents into the pharynx and the corresponding injury, and is one of the forms of gastroesophageal reflux As otolaryngologists become more comprehensive in their knowledge and understanding of laryngopharyngeal reflux, the prevalence of this disorder is becoming more prominent. The literature reports that up to 10% of patients attending otolaryngology are patients with pharyngeal reflux, and the disease is also closely related to voice abnormalities. I. Mechanisms of tissue damage caused by pharyngeal reflux 1. Direct stimulation, acid and pepsin from reflux directly stimulate the pharyngeal mucosa. 2. Vagal reflexes, whether acid reflux or non-acid reflux, can stimulate the distal esophagus and cause vagal reflexes, which can cause damage to the vocal fold mucosa by triggering chronic coughing and throat clearing. II. Common symptoms The symptoms are complex and varied, such as throat clearing, chronic cough, heartburn or regurgitation, foreign body sensation or hoarseness in the pharynx, choking, reflux, vomiting of bitter water, and in pediatric patients, may also cause apnea, recurrent upper respiratory tract infection, laryngeal cartilage softening, subglottic stenosis, sinusitis, otitis media, and chronic nasal pain. III. Relationship between LPR and other diseases 1. Lin et al. found that laryngeal reflux can cause laryngeal inflammation and enhance the carcinogenic effect of tobacco and alcohol, but it is not an independent risk factor for laryngeal cancer; 2. The relationship between LPR and esophageal adenocarcinoma laryngeal reflux symptoms are considered to have more risk of esophageal adenocarcinoma than gastroesophageal reflux symptoms; 3. When reflux triggers intermittent airway spasm, it is easily misdiagnosed as chronic cough. pH monitoring is a valuable diagnostic modality, and there is an association between LPR and otitis media. Reflux laryngitis is often manifested as refractory laryngitis. In addition to conventional laryngitis treatment, appropriate treatment for laryngeal reflux needs to be considered 1. General treatment Lifestyle changes are recommended, such as elevating the head of the bed, avoiding tight clothing, maintaining an upright position after meals, and a diet high in protein! High fiber! Low fat as the principle, control the body mass, avoid tobacco and alcohol! Strong tea! Coffee! Coke and other stimuli, eat less and more meals, stop eating 4 hours before bedtime, chew more gum to promote saliva secretion, improve the ability to clear the esophagus, life behavior and diet habit improvement is important for the relief of symptoms. 2.Medication Neutralizing gastric acid drugs, such as Vedimax; antacids, receptor antagonists such as: ranitidine; proton pump blockers, such as: omeprazole, etc., the course of treatment is generally long, at least 6 weeks. 3, high volume fluid reflux with lower esophageal sphincter insufficiency where the above treatment is ineffective can be considered surgical treatment, complete fundoplication and partial fundoplication, etc.