Leuprolide is usually given in three injections to treat adenomyosis. After the three injections, the ultrasound is repeated to check the condition of the uterus before deciding on further treatment options. Leuprolide has many side effects and is harmful to the liver. A few liver function abnormalities are hepatic ascites that occur after leuprolide application. Gastrointestinal reactions, such as nausea, vomiting, and loss of appetite. There is also a rise in blood uric acid and urea ammonia in the urinary system, non-menstrual bleeding and increased leucorrhea of secretions in women, etc. There will also be a series of complications and side effects such as anemia, leukopenia, acne, rash, and itching.