The use of cephalosporin antimicrobial drugs is generally recommended to do a skin test, so as not to cause an allergic reaction, resulting in shock, seriously endangering the health of patients. Cephalosporin antibacterial drugs have a certain bactericidal effect, can treat respiratory tract infections, skin and soft tissue infections, urinary tract infections and so on. However, due to the human body when using cephalosporin antibacterial drugs, it is easy to have an allergic reaction, and in severe cases, anaphylactic shock will occur, and there is a possibility of death. Therefore, before patients use cephalosporin antibacterial drugs, it is generally recommended to do a skin test, so as to clarify whether there is a contraindication to the drug. It should also be noted that, during the use of cephalosporin antibacterial drugs, patients need to prohibit the use of alcohol, as well as the consumption of alcohol-containing food, so as not to cause a disulfiram-like reaction, which can also easily lead to respiratory distress, or even death. During the treatment with cephalosporins, patients need to follow the doctor’s instructions for regular checkups, in order to understand the degree of recovery of the disease. In daily life, it is necessary to ensure sufficient rest time, do not overwork, so as not to damage the health of the body.