Headache and nausea in the middle of the night: The first thing to consider is whether the patient has a migraine. Migraine can be triggered by many factors, for example, if the patient has recently been overworked or under stress or excessive tension, migraine can be triggered. In addition, whether the patient has eaten spicy or irritating foods or taken cold foods such as seafood and crabs before going to bed can trigger headache and nausea in the middle of the night. There are also common reasons that patients may have insufficient blood supply to the brain, or whether patients have aura of cerebrovascular disease. At this time, if the patient’s symptoms are not relieved, it is recommended that the patient can go to the hospital and under the guidance of a doctor for relevant examinations to avoid further aggravation of the condition.