The main medications used to treat premature ejaculation include selective 5-HT reuptake inhibitors and lidocaine spray. 1. 5-HT reuptake inhibitors, such as dapoxetine. Such drugs can block the in reuptake of 5-HT, thus elevating the concentration of 5-HT in the central nervous system. It has been found that 5-HT receptors play a key role in the central control of ejaculation. Contraindications include people with a past history of severe cardiovascular disease, severe hepatic or renal impairment, and peptic ulcers. 2. Lidocaine spray is intended to be sprayed on the glans to maximize the patient’s ejaculatory latency. Contraindications include severe hepatic and renal impairment, heart failure, and hypovolemic shock. In summary, the specific treatment of premature ejaculation drugs should be under the guidance of a regular doctor, the correct use of drugs, avoid self-use.