The presence of overlapping infection of HCV and HBV affects the prognosis of liver disease HCV infection in patients with chronic liver disease, especially dual infection of HBV and HCV, may accelerate the progression of liver disease. Viral hepatitis (viralhepatitis) is a group of infectious diseases caused by a variety of different hepatitis viruses, mainly liver damage, according to the pathogenic diagnosis, there are at least five types of hepatitis viruses, namely hepatitis A, B, C, D and E viruses, which cause viral hepatitis A, B, C, D and E, respectively, namely hepatitis A (hepatitis A), hepatitis B ( hepatitis B), hepatitis C), hepatitis D) and hepatitis E). Another type of viral hepatitis, called hepatitis G, is less common. How to effectively prevent the existence of HCV and HBV overlap infection? 1.Strengthen dietary hygiene management, water source protection, environmental hygiene management and harmless treatment of feces, and improve personal hygiene. 2, strengthen the disinfection of various medical devices, injections to implement one person one tube, or use disposable syringes, medical devices to implement one person one use one disinfection. Strengthen the management of blood and blood products, and do a good job of HBsAg testing of products, and those who are positive are not allowed to sell and use. Do not transfuse blood or blood products when not necessary. Use toiletries and eating utensils exclusively. Wash hands with soap and running water after contact with patients. Protection of infants to cut off mother-to-child transmission is the focus of prevention. Babies born to mothers who are positive for HBsAg, especially those who are also positive for HBeAg, must be injected with hepatitis B specific immunoglobulin and/or hepatitis B vaccine immediately after birth.