The 13-valent pneumonia vaccine consists of four doses and is given to infants from 6 weeks to 15 months of age to boost their immunity and to administer preventive vaccinations against diseases caused by Streptococcus pneumoniae. Therefore, vaccination is usually recommended in the second, fourth and sixth months of life, with a booster dose at 12-15 months of age. The 13-valent pneumonia vaccine is given intramuscularly to prevent 13 diseases caused by Streptococcus pneumoniae, such as pneumonia, meningitis, septicemia, otitis media and sinusitis. Vaccination with the 13-valent pneumonia vaccine can effectively reduce the risk of these diseases and produce long-lasting immunity. However, it should be noted that the vaccine does not guarantee the prevention of diseases such as pneumonia caused by viral types or other microorganisms that are not covered by the vaccine. Therefore, parents should still be aware that when infants develop cough, coughing, chills, perioral herpes, and other discomforts, they should promptly seek medical attention to identify the cause and provide treatment. In addition, if the infant has an acute infectious disease or is in a febrile period, vaccination should be delayed until the original disease is cured. Some infants may have adverse reactions after vaccination, such as local redness, swelling, hard knots, pain, hives, decreased appetite, difficulty sleeping, and low fever, which are normal and will generally subside within a few days. However, if adverse reactions persist or worsen, prompt medical consultation should be made.