New treatment advances for man with rare “protein lung”

       A 30-year-old man, Zhang Bing (a pseudonym), was recently diagnosed with the rare “alveolar protein deposition disease,” which affects only one person in 2 million. The protein-like material secreted on the surface of the alveoli blocked the air bubbles causing breathing difficulties, and if left untreated is likely to be life-threatening due to respiratory failure.  Rare: protein material fills both lungs, “black lung” becomes “white lung” 30-year-old boy Zhang Bing, who lives in the rural areas of northern Jiangsu Province, began to shortness of breath after a cold more than a month ago, the activity will be serious, can be relieved after a period of rest, shortness of breath at the same time will be dry cough. In the morning, he felt uncomfortable in his throat and could not cough up phlegm, but at night, he was fine and did not feel uncomfortable and slept well. When he went to the local hospital, the doctor treated him with anti-infection treatment, but the symptoms did not improve. His family took him to a hospital in Nanjing, where he was diagnosed with “alveolar protein deposition”, commonly known as “protein lung”, but the treatment had no significant effect. Later, Zhang Bing was recommended to come to CUH for treatment.  According to Dr. Sun Siqing, deputy chief physician of the hospital’s respiratory department, Zhang Bing was found to have inflammatory and interstitial fibrosis in both lungs through chest films, CT and biopsies after admission. Zhang Bing’s lungs turned out to be “white lungs”, with a large amount of protein-like material secreted from the alveoli filling both lungs and making breathing difficult. The specialist diagnosed Zhang Bing with a very rare alveolar protein deposition disease.  Treatment: Whole lung lavage, washing out 20,000 ml of yellow liquid Dr. Sun Siqing told reporters that the most effective treatment for the disease “protein lung” is high-volume whole lung lavage. In order to prevent lung edema from affecting the normal function of the lungs after lavage, doctors will first lavage one side of the patient’s lung, and then lavage the other side of the lung after the situation has stabilized.  On March 10, Zhang Bing underwent lavage of the right lung after general anesthesia. A double-lumen organ cannula was inserted through the mouth, the left lung was ventilated with pure oxygen, the breathing pathway of the right lung was clamped shut, the lavage pathway was connected, and saline was injected and lavaged repeatedly. The right lung lavage is over, Zhang Bing feel more smooth breathing, shortness of breath and cough is also relieved. 18, the doctor discretion for his left lung lavage, and washed out about 10,000 ml of yellow liquid, double lung washed out a total of about 20,000 ml of yellow turbid liquid, into a 500 ml glass bottle to 40 bottles.  Experts: the cause is still unclear, or lack of genes Sun Siqing, deputy chief physician, pointed out that the cause of “protein lung” is still unclear, there is no symptomatic treatment of the special drug. The current consideration of “protein lung” may be related to the lack of genes, there is no relevant effective prevention methods, only to remind everyone once the breathing problems, shortness of breath and coughing these uncomfortable symptoms best immediately seek medical attention.