A headache with a runny nose may be caused by a cold. Cold, also known as upper respiratory tract infection, is caused by viral infection and the patient may have headache, fever, and clear runny nose. Anti-cold medications should be given, commonly used are cold capsules, cold flush, aminoglutethimide, and if necessary, oral acetaminophen, ibuprofen, indomethacin and naproxen can also be given for treatment. At the same time, some patients may also be caused by paranasal sinusitis, mainly seen in acute paranasal sinusitis, including maxillary sinusitis, frontal sinusitis and mandibular sinusitis. In patients with frontal sinusitis, the symptoms are mainly severe in the morning and less severe in the afternoon; in patients with maxillary sinusitis, the symptoms of the main headache are mild in the morning and severe in the afternoon, and CT examination of the paranasal sinuses can make a clear diagnosis. If a patient is found to have acute paranasal sinusitis, anti-inflammatory treatment should be given promptly, mainly cephalosporin antibiotics, metronidazole or tinidazole, to prevent the transformation into chronic paranasal sinusitis. Paranasal sinusitis, mainly caused by prolonged cold.