Multi-organ failure MOF is a clinical syndrome that sequentially and habitually produces the failure of two or more organs due to an acute and intense pathogenic factor acting on the organism, with a high mortality rate and great danger to the patient. The causes of MOF, severe infection, severe trauma, shock, massive blood loss, acute myocardial infarction, acute aortic coarctation, massive infusion, acute pancreatitis, acute obstructive bile duct disease, acute respiratory disease are all causes of multiorgan failure. The underlying mechanism of multivisceral failure is a systemic inflammatory response syndrome with a systemic inability to oxygenate effectively. The organs most likely to be involved in multiorgan failure are the lungs, liver, heart, gastrointestinal tract, kidneys, and nervous system. Typical clinical manifestations of multiorgan failure include dyspnea, hypoxemia, hypotension, gastrointestinal bleeding, abdominal distention, skin petechiae, and oliguria, in addition to the primary manifestations. The mortality rate of multiorgan failure can range from 30 to 90 percent. The main approach to treatment is to actively treat the primary disease and try to keep the failure in one organ. Replenish blood volume, anti-infection, apply vasoactive drugs, adjust cardiac pre’ afterload, correct acidosis, correct electrolyte disorders, replenish vitamins, maintain nutritional balance, maintain intestinal function, apply Echocardium and artificial heart if necessary, ventilator support, hemodialysis, etc. In conclusion, it is important to recognize multi-organ failure, pay attention to multi-organ failure, and pay attention to the prevention and treatment of primary diseases.