Isaac syndrome (Isaac syndrome) requires hospital tests such as electromyography, muscle strength, electroencephalogram, and cranial MRI of the extremities. Isaac syndrome is a disease of unknown origin, possibly immune-related, causing mainly muscular symptoms in the limbs. The main manifestation is muscle crepitus, a persistent muscle tremor described as “a bag of worms moving”, sometimes accompanied by hand and foot spasms, intermittent painful spasms, increased sweating and pseudomyotonia. Treatment: Carbamazepine or phenytoin sodium can be used to relieve symptoms. Hormones can also be added, and the effect is still possible.