The main drugs for the treatment of chronic atrophic gastritis are gastric mucosal protectants, gastrointestinal stimulants, antibiotics, vitamin B12 and so on. 1. Gastric mucosal protective agent: including magnesium aluminum carbonate, teprenone, etc., can play a role in protecting the gastric mucosa, promote tissue repair and ulcer healing purposes. 2. Gastrointestinal stimulants: they can promote gastrointestinal motility and are suitable for the treatment of patients with abdominal distension and other uncomfortable symptoms; such drugs include domperidone, mosapride, and so on. 3. Antibiotics: penicillin, metronidazole, clarithromycin, etc., mainly quadruple therapy for the treatment of patients with atrophic gastritis accompanied by Helicobacter pylori infection. 4. Vitamin B12: Vitamin B12 can be used for the treatment of pernicious anemia. Patients with chronic atrophic gastritis who need to use medication should use medication under the guidance of a doctor, and not blindly use medication on their own.