Proton pump inhibitors are preferred for acid suppression in peptic ulcer and are commonly used, such as omeprazole, lansoprazole and rabeprazole. Proton pump inhibitors (PPI) have a strong acid inhibition effect, which can make the stomach reach the level of no gastric acid, and at the same time have the characteristics of acid inhibition for a long time. The healing rate of gastric ulcer and duodenal ulcer is 80%~96% and 90%~100% respectively, which is higher than that of other acid-suppressing drugs such as H2 receptor antagonists, so PPI is the first choice of drug for the treatment of peptic ulcer. Commonly used PPIs are omeprazole, lansoprazole, rabeprazole, pantoprazole and so on. People with severe hepatic or renal insufficiency should use this class of drugs with caution. Common adverse reactions to taking this type of drug include diarrhea, abdominal pain, flatulence, constipation, headache, and nausea. Patients with peptic ulcer should go to the hospital in time, and use acid-suppressing drugs under the guidance of professional doctors. For those who are positive for Helicobacter pylori, they also need to eradicate Helicobacter pylori, and they should avoid self-medication in order to avoid adverse reactions.