Drugs for the treatment of low glomerular filtration rate need to be chosen according to the cause of the disease. The common causes of low glomerular filtration rate are acute glomerulonephritis, chronic glomerulonephritis, diabetic nephropathy, etc. Furosemide, hydrochlorothiazide, captopril, insulin and other medications can be used according to the different causes. 1. Acute glomerulonephritis: Acute glomerulonephritis can lead to transient renal hypoplasia, causing low glomerular filtration rate. It can be treated with diuretics such as furosemide and hydrochlorothiazide. 2. Chronic glomerulonephritis: chronic glomerulonephritis can lead to glomerular filtration hypoperfusion and low glomerular filtration rate. The condition can be controlled by using drugs such as hydrochlorothiazide and captopril. If there is more urine protein, glucocorticoids such as prednisone and cytotoxic drugs such as cyclophosphamide can be applied without contraindications. 3. Diabetic nephropathy: Diabetes mellitus can lead to glomerular damage, causing diabetic nephropathy, which results in low glomerular filtration rate. Acarbose, insulin and other drugs can be used to control blood glucose, to avoid further damage to kidney function due to elevated blood glucose, and at the same time with the use of captopril and other drugs for comprehensive treatment. All the above medications should be used under doctor’s guidance, avoid self-medication. If patients find that the glomerular filtration rate is low, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.