Sweating on movement is often due to cholinergic urticaria caused by excitation of the patient’s sympathetic nervous system and cholinergic nerves. Patients can take oral antihistamines, such as ketotifen or cetirizine. Sweating upon movement is mostly diagnosed clinically as cholinergic urticaria. Cholinergic urticaria is often associated with mental, exercise or heat allergies and is mostly seen in young people. When exercise, emotional changes, hot food, alcohol, hot baths, or febrile illnesses increase body temperature by 0.7-1°C, sweating can occur, accompanied by itching or skin damage. The pathogenesis of cholinergic urticaria, which is currently considered to be probably non-immune, may be related to body temperature dysregulation leading to degranulation. Exercise, heat, and emotions can slightly increase body temperature, and the heat-increasing blood flow stimulates the thermoregulatory center of the brain, causing impulses from the cholinergic nerves of the parasympathetic nervous system, which release acetylcholine in the patient’s skin. Cholinergic urticaria occurs in patients who are allergic to acetylcholine or due to cholinesterase deficiency. The disease is relatively rare, mostly in young people. Some patients can heal spontaneously after thermal adaptation, and the use of atropine and local anesthetics can inhibit the occurrence of the disease. The disease usually improves gradually after several years, and can also be treated effectively with oral antihistamines, such as ketotifen or cetirizine.