Secondary epilepsy, also known as symptomatic epilepsy, is caused by various definite or possible central nervous system lesions, such as congenital malformations, craniocerebral injuries, central nervous system infections, poisoning, brain tumors, cerebrovascular disease, neurodegenerative diseases, etc. Its treatment is consistent with that of epilepsy due to other etiologies, including pharmacotherapy and surgery. When the diagnosis of epilepsy is established, the patient should be treated with appropriate medication according to the cause, age and seizure form of epilepsy under the guidance of a professional neurologist. The patient should be aware of regular review during the treatment process to detect the efficacy and toxic side effects of the medication, and the medication can be reduced and discontinued under the guidance of the physician after achieving long-term control. If the treatment with standard medication is not effective, or if there is a clear pathogenic focus in the brain and the risk of surgery is small, surgery can be used to control seizures after a comprehensive evaluation. Surgical procedures include resection, palliative surgery neuromodulation surgery, etc. The appropriate surgical procedure should be selected according to the patient’s condition. In addition, lifestyle interventions in epilepsy treatment are also very important, both to take medication on time and in the right amount, and to maintain healthy work and rest habits to avoid exertion, hunger, emotional excitement or infection to maximize seizure control. In summary, the treatment of secondary epilepsy mainly includes medication and surgery, and the appropriate treatment plan should be chosen under the guidance of a professional physician, while paying attention to lifestyle modifications to pursue the best treatment effect.