Recurrent spontaneous abortion refers to 2 or more consecutive spontaneous abortions before 20 weeks of gestation with the same sexual partner and is a common condition in women of childbearing age. Its pathophysiology is complex, with many debates and uncertainties, and the etiology and treatment are mostly based on experience.
I. Influential factors causing recurrent miscarriage
1.Adverse factors in the environment: chemical substances, radiation, severe noise and vibration, etc.
2.Adverse psychological factors.
3.Excessive physical labor.
4, bad habits: alcoholism, smoking, drug addiction, staying up late, etc.
5, age factors: pregnant women or their spouses are younger than 18 years old or older than 35 years old, resulting in aging of eggs and chromosomal abnormalities of sperm.
Second, the main causes of recurrent miscarriage
1, uterine anatomical abnormalities: congenital malformations of the uterus, uterine adhesions, uterine fibroids and adenomyosis, cervical insufficiency, etc.. Most of them are late miscarriage or preterm birth which occurs after 13 gestational weeks.
2, endocrine abnormalities: mainly gynecological endocrine abnormalities, such as luteal insufficiency, polycystic ovary syndrome, lactogen disorder, etc. Serious endocrine disorders such as diabetes mellitus, hyperthyroidism or hypothyroidism can also lead to miscarriage.
3, pre-thrombotic state or thrombotic disease: the risk of venous thrombosis increases 5-6 times in the hypercoagulable state of pregnancy.
4.Immune function abnormalities or disorders: manifested as alloimmune disorders with insufficient production of closed antibodies; antiphospholipid antibody formation, causing the formation of placental microcirculation thrombosis, etc.
Treatment of recurrent miscarriage
1.Psychological support.
2.Progesterone treatment.
3.Metformin.
4.Aspirin.
5.Heparin.
6.Immunomodulation.
7.Father lymphocyte immunity.
8, Chinese medicine treatment: Chinese medicine to prevent and control spontaneous abortion is a broad research field, the research of Chinese medicine mainly starts from the symptomatology, identify and treat, and combine with the pathology of Western medicine, to carry out the overall regulation, in order to achieve the purpose of consolidating the punch and the fetus, and to cultivate the root.