Cramps in the legs of middle-aged patients are commonly caused by cold leg muscles and osteoporosis, as follows: first, cold leg muscles: middle-aged patients’ metabolic level slows down, while lack of physical exercise can cause changes in blood circulation in the legs, which can easily get cold and produce leg muscle spasm and tension, resulting in cramping symptoms; second, osteoporosis: prolonged partial diet, lack of exercise, and lack of vitamin D can cause bone Second, osteoporosis: prolonged partial diet, lack of exercise, and lack of vitamin D can cause osteoporosis, which leads to increased neuromuscular excitability, and patients are prone to leg cramps at night with leg pain. Bone density test will reveal the degree of osteoporosis, and timely supplementation of calcium and vitamin D, as well as strengthening exercise and balanced diet, will significantly improve the symptoms of cramps.