Major triple positive carrier may become minor triple positive, patients need to cooperate with the doctor for treatment. Usually patients with hepatitis B triple positive are in the more active replication period of hepatitis B virus, but it does not mean that the condition is serious, and some patients with mild condition do not need special treatment. If the patient has liver function damage, he needs to take nucleoside analogs such as entecavir, tenofovir or interferon-alpha under the guidance of the doctor to carry out antiviral treatment. And some patients can also be combined with the use of silymarin preparations and glycyrrhizic acid preparations for anti-inflammatory and hepatoprotective treatment. At the same time, patients with obvious symptoms, severe condition or jaundice need to rest in bed and avoid overwork. Patients also need to pay attention to rational planning of diet, avoid drinking alcohol, and consume high-calorie, high-protein and high-vitamin food, which is conducive to the recovery of the condition. Most patients have a better prognosis after active systematic treatment, and some patients may also change to minor triple positive. It is recommended that patients with hepatitis B triple positive actively cooperate with doctors to carry out antiviral treatment and do a good job of their own care, it is possible to change into small triple positive.