Mild drug-associated interstitial nephritis can be cured by stopping the medication in time; however, most drug-associated interstitial nephritis needs medication to be cured. Acute interstitial nephritis is one of the most common types of drug-related renal damage. It is mainly characterized by skin rash, fever, oliguria, hematuria, proteinuria, etc., and glomerular function abnormalities of varying degrees, such as decreased glomerular filtration rate, increased blood creatinine and urea nitrogen, etc. If drug-related interstitial nephritis can be cured in time at the early stage of kidney injury, it may be cured. If it can be detected in time at the early stage of renal injury and stop using medication, there is a certain possibility of self-healing. However, most acute interstitial nephritis requires drug treatment. Clinical treatment mostly uses glucocorticoids such as prednisone, which have immunomodulatory effects and can reduce the exudation of inflammatory factors. If there is no obvious contraindication, immunosuppressants such as cyclophosphamide or cyclosporine can also be added. All of the above medications should be used under the guidance of a doctor, avoid self-medication. Drug interstitial nephritis patients are recommended to go to the regular hospital in time, under the guidance of the doctor standardized treatment.