Vaccination can effectively play a role in preventing, controlling and even eliminating infectious diseases. Most of the vaccines in China are for the whole population, but there are some adults in an abnormal state of the organism who cannot be vaccinated, and the following are usually unsuitable for vaccination: 1. early pregnancy: if an adult is in an early state of pregnancy, vaccination is not clinically recommended to avoid fetal malformations; except for some safer vaccines, such as hepatitis B vaccine, pregnancy does not affect 2. use of immunomodulatory drugs: adults who are using immunomodulatory drugs within the last 6 weeks, including gammaglobulin and immunoglobulin injections, are likely to cause interference with passive antibodies, so vaccination should be postponed; 3. body fever: adults who are in a febrile state on the day of vaccination, vaccination may aggravate the fever, and there is also a situation that affects the body’s immunity Vaccination is not recommended for patients with acute infectious diseases: chickenpox, measles, mumps, and influenza are common, and vaccination is not recommended during the onset of infectious diseases, as the vaccine may aggravate the adult’s condition and may cause adverse reactions; 5. 7. acute diseases: if there are skin diseases such as dermatitis and eczema at the vaccination site, it is recommended to avoid vaccination temporarily and vaccination can be done after the disease is cured; 7. acute diseases: adults with infections in the respiratory, digestive and urinary tracts, as well as acute diseases such as acute hepatitis and cholecystitis, should generally avoid vaccination and can be vaccinated after the disease is cured; 8. acute attacks of chronic diseases: such as heart disease Heart failure, chronic liver disease, hypertension, diabetes mellitus, unstable condition, observation period of drug treatment, medication adjustment period, etc. are not recommended to be vaccinated, wait for the condition to stabilize before vaccination; 9. Vaccination is not recommended and will affect the production of antibodies.