We want to rehabilitate mycoplasma! First of all, there is a concept that needs to be clarified: “infection and residence”. The human body is not as “clean” as people generally think. There are a large number of microorganisms residing in the body, and the body has a perfect immune system, under normal circumstances, microorganisms and the body to achieve a dynamic balance, the medical term “flora balance”, and the host microorganisms are called “normal flora”. When the local environment changes and the local resistance decreases, pathogens take advantage of the situation and multiply in the local area, damaging and devouring the normal tissues, resulting in symptoms and discomfort, which is called “infection”. For example, Staphylococcus aureus does not cause any problem because of the protection of the “skin barrier”, at this time, it is the “normal flora”; when injured, the “skin barrier” is damaged, it can easily enter the skin. is damaged, it can easily enter the subcutaneous tissue to multiply and appear “infection”. At this time, this “normal flora” becomes “environmental pathogenic bacteria”. After the skin is broken, if it is not handled in time and correctly, the wound will soon become “septic”. So mycoplasma is widespread in nature, and it can also be one of the “normal flora” in the human body. Once mycoplasma infects the urethra, the patient can develop symptoms of urethritis, and can develop chronic prostatitis, testicular and epididymitis, and can also cause vas deferens obstruction leading to azoospermia. Mycoplasma also continues to infect the seminal tract, seminal vesicles and testes, affecting the quality of sperm and semen and causing infertility. It has been observed that mycoplasma can also cause infertility through the following links 1. Destruction of spermatogenic cells: There are a large number of spermatogenic cells in the varicocele of the testis, which develop and reproduce to form spermatozoa. When mycoplasma enters the testicular varicose ducts from the urethra and prostate, it destroys the spermatogenic cells, making the “spermatogenic factory” produce shoddy products, leading to infertility; 2, increased sperm deformity: mycoplasma infection leads to increased sperm deformity is another feature of infertility. According to clinical observation, in such infertility patients, the sperm deformity rate can sometimes be as high as 80%; 3, interference with sperm movement: sperm movement is an important function of healthy sperm, is an important indicator of whether sperm can conceive, and the movement of sperm must have a certain speed and frequency. After mycoplasma infects sperm, it often attaches to the head and tail of the sperm, making the whole sperm hung with attachments of varying sizes, resulting in weak sperm swimming and entanglement with each other, leading to infertility; 4, the number of sperm with the ability to conceive is reduced, with reduced motility and abnormal morphology, and some have low or lost ability to enter and combine with the egg; 5, mycoplasma produces neuraminidase-like substances that interfere with the union of sperm and egg. This is one of the causes of infertility caused by mycoplasma infection; 6. Mycoplasma solium infection also has common antigens with sperm membranes, which may lead to immune infertility once infected.