Trigeminal neuralgia is a paroxysmal and severe pain in one or more branches of the trigeminal nerve, usually in the mandibular and maxillary branches of the distribution area. The pain often comes on suddenly and is known as “the first pain in the world”, which is a sharp pain like electric shock, cutting or burning, tearing, lasting for several seconds to several minutes and then stopping suddenly. The pain is often triggered by non-injurious stimuli such as washing, brushing, chewing and speaking, and is mostly caused by compression of the trigeminal nerve, tumor of the semilunar ganglion or vascular malformation. For the treatment of trigeminal neuralgia, the oral medications carbamazepine or gabapentin are commonly used. However, they become increasingly ineffective and have increasing side effects when taken later. Minimally invasive radiofrequency treatment in the pain department is less invasive and more effective, especially for patients who are older, or have other diseases that cannot tolerate surgical open microvascular decompression procedures. It is currently recognized worldwide as the best means of treating trigeminal neuralgia.