Sleep-related teething disorder refers to the behavior of unconscious grinding or clenching of upper and lower teeth during sleep or waking hours, which is also called “night grinding” because it is often accompanied by a “gurgling” sound and occurs mostly during nighttime sleep. Sleep-related teething disorder is a sleep-related movement disorder that predisposes to tooth wear, painful spasms of the masticatory muscles, temporomandibular disorders (TMDs), and headaches. To investigate the risk factors associated with sleep grinding in adolescents, Tommaso et al. from the Department of Orthodontics, University of Turin, Italy, performed a systematic evaluation and published it in a recent issue of the European Journal of Orthodontics. The authors searched the medical literature system for articles on risk factors associated with sleep teething disorders in adolescents aged 11-19 years, and four articles were selected, all using cross-sectional and randomized studies. By analyzing lifestyle, sleep status, depression and stress status, tooth wear, sleep breathing disorders, TMDs, sociodemographic information and ethnic background, orthodontic treatment, tobacco and alcohol intake, the articles confirmed that sleep disorders (especially snoring), headache, masticatory muscle fatigue and tooth wear are closely associated with sleep-related molar disease in adolescents aged 11 to 19 years. The association between sleep disorders, especially snoring, and sleep-related teething disorder in adolescents appears to be more pronounced than other factors, with patients with poor intraoral hygiene during sleep showing relatively more daytime sleepiness, difficulty waking up in the morning, and frequent headaches. The current study suggests that sleep-related teething disorder is associated with obstructive sleep apnea syndrome (OSAS). Some researchers have also proposed the hypothesis that sleep-related teething is a way to restore airway patency after OSAS apnea, although more research is needed on this hypothesis. Sleep-associated teething disorder and OSAS patients both share common features such as snoring, daytime sleepiness, and frequent headaches, but the causal relationship between the two does not appear to be obvious. Physiological evidence supports that OSAS microarousals can produce teeth grinding symptoms; however, teeth grinding symptoms do not necessarily occur after OSAS apnea, which also suggests that OSAS does not appear to be a direct cause of sleep-associated teeth grinding. Dental wear: Chewing muscle fatigue as well as dental wear appear to be associated with sleep-related teeth grinding, but only one article has suggested this potential link. Moderate tooth wear was reported in 51% of adolescents in Birmingham, UK. Among 295 12-year-olds in Brazil, the prevalence of tooth wear was 26.90 percent. From a clinical perspective, sleep-related teething disorder does not necessarily lead to tooth wear, but there is still some risk. Depressive states have been shown to have a moderate association with sleep-related teething disorder in adolescents. However, little is known about the significance of these associations to establish a causal relationship. In studies of the association of sleep-related teething disorder with TMDs, sleep-related teething disorder appears to precede excessive TMJ and masticatory muscle motion and muscle soreness. These may have an important role in the identification of risk factors associated with sleep-related teething disorder in adolescents and in improving the quality of life of adolescent orthodontic patients. Only four articles from the cross-sectional study were included in the current study, and further research is needed to draw a definitive conclusion. However, this study found that sleep disorders showed the strongest correlation with sleep-related molarity, while occlusal relationships showed little correlation with sleep-related molarity. From a clinical perspective, further research on sleep breathing disorders could be more helpful in adolescents with sleep-related teething disorder.