Closed mouth refers to closed pimples (whiteheads). Papular acne and whiteheads are different gradations of acne severity, the difference being different symptoms, severity, and treatments. 1. Different symptoms: papules are small, red bumps with small pustules at the top. While whiteheads acne follicle mouth is blocked by keratinocytes, sebum filling, localization will form white keratinized pimples, and the surface of the pimples are covered with epidermis, and do not communicate with the outside world. 2. Different ranges: the shape of the papule is diverse, the top can be pointed, such as condyloma acuminatum, rounded, such as furfuraceous folliculitis, flat, such as seborrheic keratosis, or depressed in the middle, such as the umbilicus, such as infectious molluscum contagiosum; papules including whiteheads acne. 3. Treatment methods are different: general patients with whiteheads acne follow the doctor’s prescription of vitamin A acid cream, isotretinoin gel and other vitamin A acid drugs, or azelaic acid gel, benzoyl peroxide gel and other acne dissolving medication can be drug treatment. And patients with papules, in addition to the above medication, but also according to the different conditions of the choice of different treatment drugs, such as seborrheic keratosis can be used externally retinoic acid cream, if necessary, to give the laser, freezing and other physical therapy approach. Furfura folliculitis can be used topically with ketoconazole, sertaconazole cream, etc., and oral itraconazole capsules, etc., if necessary. It is recommended that patients with pimples, whiteheads acne need to consult a doctor in a timely manner, the doctor will choose the appropriate measures for treatment according to the severity of the patient’s condition.