Swelling of the face due to toothache is caused by inflammation of the soft tissues of the tooth turnover, resulting in edema around it. Its etiology is mostly considered to be the result of diseases such as wisdom tooth pericoronitis, endodontitis, and apical periodontitis. 1. Wisdom tooth pericoronitis: The cause of wisdom tooth pericoronitis is related to insufficient eruption of wisdom teeth, bacterial infection, low immunity and other factors. Patients will experience toothache, and as the disease progresses, the inflammation can extend to the face, resulting in facial swelling. 2. Pulpitis: Pulpitis may be caused by bacterial infection, physical and chemical stimulation. Patients mainly present with toothache, which can be temperature-irritating pain, spontaneous pain, radiating pain, etc.. When the symptoms are severe, the pain can be launched to the same side of the jaw and face, with facial pain and swelling. 3. Periapical inflammation: Periapical inflammation is mainly caused by bacterial infection, trauma, physical stimulation and other factors. Patients will have toothache, and when the inflammation spreads, it can invade to the face, and face swelling occurs. If the patient has a toothache and swollen face, he or she should go to a regular hospital and undergo a relevant examination to find out the cause of the disease.