Mycoplasma (Mycoplasmal) is a prokaryotic organism, the smallest in size and simple in structure among microorganisms that have the ability to reproduce and synthesize their own macromolecules autologously. Mycoplasma has no cell wall and does not contain any cell wall components, so it is not sensitive to penicillin and other antibiotics that have the ability to degrade or inhibit peptide glucan synthesis. It is the smallest microorganism that can be found growing and reproducing in inanimate medium. Mycoplasma has a variety of body shapes, basically spherical, but can also be spherical or filamentous, and its colonies are the size of a pinpoint, so it is also called micro mycoplasma. Mycoplasma solium and mycoplasma humanum can cause urinary tract infections in humans. It is mainly transmitted through sexual contact, but a few can also be transmitted indirectly. The urinary system is its susceptible cells. The biggest difficulty in the treatment of mycoplasma is the constant infection of drug-resistant mycoplasma. In recent years, our research is the reversal of drug-resistant mycoplasma by Chinese herbal medicine and the combination of Chinese and Western medicine to reduce drug resistance.