Prednisone is a glucocorticosteroid commonly used in clinical practice. Short-term high dose application may have peptic ulcer, neuropsychiatric system symptoms, and taking it for more than 2 weeks may cause side effects such as obesity, hypertension, and osteoporosis. Prednisone is mainly used for the treatment of allergic, autoimmune and inflammatory diseases, such as connective tissue disease, systemic lupus erythematosus, bronchial asthma, vasculitis, etc. Usually, prednisone is a short-term application within 2 weeks, and small dose application is not a big problem. However, if applied in large doses, it can cause bleeding from peptic ulcers, as well as induce mental excitement and fall into a state of hyperactive delirium. If the drug is applied for more than 2 weeks, it can be considered as long-term application, which may lead to water and sodium retention, and also affect the metabolism of fat, protein and glucose, and even cause centripetal obesity, hypertension, hyperglycemia and osteoporosis. In addition, it can reduce the body’s resistance, making patients susceptible to various infections, including pneumonia and fungal diseases. Therefore, when applying prednisone, patients should not increase the dose of the drug on their own or stop it suddenly or reduce it too quickly, but need to use it reasonably under the guidance of a doctor to avoid discomfort or aggravation of the disease.